| Dec. 16 | Chiefs (-3.5) vs. Chargers | 34-28 | Favorite | Over (50) |
| Dec. 18 | Patriots vs. Colts (-1.5) | 17-27 | Favorite | Under (47) |
| Dec. 19 | Cowboys (-12.5) vs. Giants | 21-6 | Favorite | Under 43.5 |
| Dec. 19 | Titans vs. Steelers (-1.5) | 13-19 | Favorite | Under (43.5) |
| Dec. 19 | Jets (+10) vs. Dolphins | 24-31 | Favorite | Over (42) |
| Dec. 19 | Texans (+6, +220 ML) vs. Jaguars | 30-16 | Underdog | Over (40.5) |
| Dec. 19 | Cardinals vs. Lions (+13, +500 ML) | 12-30 | Underdog | Under (48) |
| Dec. 19 | Panthers vs. Bills (-15) | 14-31 | Favorite | Over (43) |
| Dec. 19 | Bengals (+3, +130 ML) | 15-10 | Underdog | Under (44) |
| Dec. 19 | Falcons vs. 49ers (-9) | 13-31 | Favorite | Under (48) |
| Dec. 19 | Packers vs. Ravens (+9) | 31-30 | Favorite | Over (45.5) |
| Dec. 19 | Saints (+11.5, +445 ML) vs. Bucs | 9-0 | Underdog | Under (46) |
